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A little bit of sugar makes polycomb better Free
Yuri B. Schwartz * and Vincenzo Pirrotta*
Department of Molecular Biology and Biochemistry, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA *Correspondence to:Yuri B. Schwartz, Tel: +1 732 445 6896, E-mail: schwartz@biology.rutgers.edu; Vincenzo Pirrotta, Tel: +1 732 444 2446, E-mail: pirrotta@biology.rutgers.edu
J Mol Cell Biol, Volume 1, Issue 1, October 2009, 11-12,  https://doi.org/10.1093/jmcb/mjp008

Transcriptional repression by Polycomb group (PcG) proteins is now sweetened by the discovery of the essential role of O-GlcNAc glycosylation in the process. PcG protein polyhomeotic may be the key target, but alternative or additional functions including repression of transcription through glycosylation of the C-terminal domain of RNA polymerase II are also possible.